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GPR50

G protein-coupled receptor 50

GPR50 belongs to the G-protein coupled receptor 1 family. Even though this protein shares similarity with the melatonin receptors, it does not bind melatonin, however, it inhibits melatonin receptor 1A function through heterodimerization. Polymorphic variants of this gene have been associated with bipolar affective disorder in women.

Gene Name: G protein-coupled receptor 50
Family/Subfamily: GPCR , Orphan-A
Synonyms: GPR50, G protein-coupled receptor 50, Mel1c, Melatonin-related receptor, MTNRL, H9
Target Sequences: NM_004224 NP_004215.2 Q13585

Publications (1)

1
The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization. Levoye A, Dam J, Ayoub MA, Guillaume JL, Couturier C, Delagrange P, Jockers R. The EMBO journal. 2006 25:3012-23. (WB; Human) [Full Text Article] [PubMed:16778767] [PMC:PMC1500982] Related Antibodies: LS-A6621.

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GPR50 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
67.2 kDa
20 µg/$150
GPR50 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
67.2 kDa
100 µg/$494
GPR50 Protein - 12.5% SDS-PAGE of human GPR50 stained with Coomassie Blue
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Wheat Germ Extract
GST
93.8 kDa
2 µg/$439
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).