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GOB5 / CLCA1
chloride channel accessory 1
GOB5 / CLCA1 is a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine.
| Gene Name: | chloride channel accessory 1 |
| Family/Subfamily: | Ion Channel , Chloride channel - calcium-activated CLC |
| Synonyms: | CLCA1, CaCC-1, CLCRG1, HCLCA1, HCaCC-1, GOB5, CaCC, CACC1, Chloride channel accessory 1, Chloride channel regulator 1 |
| Target Sequences: | NM_001285 NP_001276.2 A8K7I4 |
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