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GNRH

gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)

GNRH is secreted and then cleaved to form the 10 aa luteinizing hormone-releasing hormone (LHRH, also known as gonadoliberin-1), and prolactin release-inhibiting factor (also known as GnRH-associated peptide 1). LHRH stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutation in this gene are associated with hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been described for this gene.

Gene Name: gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: GNRH1, Gonadoliberin, LHRH, LNRH, GnRH-associated peptide 1, Progonadoliberin-1, Progonadoliberin I, Luliberin I, GNRH, GRH, HH12
Target Sequences: NM_000825 NP_000816.4 P01148

Publications (1)

1
Effect of neuronal nitric oxide synthase serine-1412 phosphorylation on hypothalamic-pituitary-ovarian function and leptin response. Damian D Guerra, Rachael Bok, Evelyn Llerena Cari, Cari Nicholas, David J Orlicky, Joshua Johnson, K Joseph Hurt. Biology of reproduction. 2020 May;102:1281-1289. [Full Text Article] [PubMed:32101284]

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).