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In non-hominoid primates and non-mammalian vertebrates, the gonadotropin releasing hormone 2 receptor gene (GnRHR2) encodes a seven-transmembrane G-protein coupled receptor. However, in human, the corresponding reading frame contains a premature stop codon, which has been suggested to encode a selenocysteine residue, but there is no solid evidence for selenocysteine incorporation (PMID: 12538601). It appears that the human GnRHR2 transcription occurs but the gene does not likely produce a functional multi-transmembrane protein. A non-transcribed pseudogene of GnRHR2 is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene.
Gene Name: | Gonadotropin-Releasing Hormone (Type 2) Receptor 2 |
Family/Subfamily: | GPCR , Releasing hormone |
Synonyms: | GNRHR2, GnRH II receptor, GnRH-II-R, Type II GnRH-R, Gnrh receptor ii, Type II GnRH receptor |
Target Sequences: | AY233133 AAL89821.1 Q96P88 |
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