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GNLY / Granulysin is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. This protein is present in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells, and it has antimicrobial activity against M. tuberculosis and other organisms. Alternatively spliced transcript variants encoding different isoforms have been identified.
Gene Name: | granulysin |
Synonyms: | GNLY, 519, Granulysin, LAG2, LAG-2, Protein NKG5, Lymphocyte-activation gene 2, T-cell activation protein 519, TLA519, NKG5, D2S69E, Lymphokine LAG-2 |
Target Sequences: | NM_012483 NP_036615.2 P22749 |
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