GNAS

GNAS complex locus

The GNAS1 gene encodes the alpha subunit of the G protein Gs, which couples receptor binding by several hormones to activation of adenylate cyclase (Hayward et al., 1998). This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contains a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript exists, and this antisense transcript and one of the transcripts are paternally expressed, produce noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.

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Products

Proteins (16)

Type

Over-Expression Lysate (10)

Recombinant (6)

Target

GNAS (16)

Publications

No (16)

Tag

6His-SUMO, N-terminus (1)

GST (1)

His (1)

Myc-DDK (Flag) (13)

Species

Human (11)

Source

293T Cells (5)

E. coli (2)

HEK 293 Cells (8)

Wheat Germ Extract (1)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

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Human GNAS Protein (Recombinant 6His-SUMO, N-terminus) (aa1-394) - LS-G64201

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human GNAS Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65818

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.5 kDa

Price:

20 µg/$1,107

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Human GNAS Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65819

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44.1 kDa

Price:

20 µg/$1,107

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Human GNAS Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65822

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44 kDa

Price:

20 µg/$1,107

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GNAS Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G107876

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44.1 kDa

Price:

100 µg/$494

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GNAS Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101461

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

27.8 kDa

Price:

100 µg/$494

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GNAS Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G120012

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44 kDa

Price:

100 µg/$494

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GNAS Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G120011

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.6 kDa

Price:

100 µg/$494

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GNAS Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123144

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.5 kDa

Price:

100 µg/$494

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Human GNAS Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76351

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.5 kDa

Price:

20 µg/$150

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Human GNAS Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76352

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.6 kDa

Price:

20 µg/$150

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Human GNAS Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76353

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

27.8 kDa

Price:

20 µg/$150

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Human GNAS Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76355

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44.1 kDa

Price:

20 µg/$150

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Human GNAS Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76354

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44 kDa

Price:

20 µg/$150

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Human GNAS Protein (Recombinant His) (aa11-230) - LS-G140872

Source:

E. coli

Sequence Length:

219 AA

Tag:

His

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

24.2 kDa

Price:

10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531

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Human GNAS Protein (Recombinant GST) (Full Length) - LS-G28658

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

72.1 kDa

Price:

10 µg/$479; 25 µg/$670

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