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GNAS

GNAS complex locus

The GNAS1 gene encodes the alpha subunit of the G protein Gs, which couples receptor binding by several hormones to activation of adenylate cyclase (Hayward et al., 1998). This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contains a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript exists, and this antisense transcript and one of the transcripts are paternally expressed, produce noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.

Gene Name: GNAS complex locus
Synonyms: GNAS, AHO, C20orf45, Extra large alphas protein, GSP, GNAS complex locus, GNASXL, NESP, PHP1B, PHP1C, PHP1A, POH, SCG6, XLalphas, GNAS1, GPSA, GSA, NESP55, Protein ALEX, Secretogranin VI
Target Sequences: NM_080425 NP_536350.2 Q5JWF2

☰ Filters
Products
Proteins (16)
Over-Expression Lysate (10)
Recombinant (6)
GNAS (16)
No (16)
6His-SUMO, N-terminus (1)
GST (1)
His (1)
Myc-DDK (Flag) (13)
Human (11)
293T Cells (5)
E. coli (2)
HEK 293 Cells (8)
Wheat Germ Extract (1)
Purified (2)
Low endotoxin level (1)
GNAS Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His-SUMO, N-terminus
1 mg/$1,679; 100 µg/$500; 20 µg/$364
GNAS Protein - Purified recombinant protein GNAS was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
45.5 kDa
20 µg/$1,107
GNAS Protein - Purified recombinant protein GNAS was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
44.1 kDa
20 µg/$1,107
GNAS Protein - Purified recombinant protein GNAS was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
44 kDa
20 µg/$1,107
Select
HEK 293 Cells
Myc-DDK (Flag)
44.1 kDa
100 µg/$494
GNAS Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
27.8 kDa
100 µg/$494
GNAS Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
44 kDa
100 µg/$494
GNAS Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
45.6 kDa
100 µg/$494
Select
HEK 293 Cells
Myc-DDK (Flag)
45.5 kDa
100 µg/$494
Select
293T Cells
Myc-DDK (Flag)
45.5 kDa
20 µg/$150
GNAS Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
45.6 kDa
20 µg/$150
GNAS Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
27.8 kDa
20 µg/$150
Select
293T Cells
Myc-DDK (Flag)
44.1 kDa
20 µg/$150
GNAS Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
44 kDa
20 µg/$150
Select
E. coli
219 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
24.2 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
GNAS Protein - 12.5% SDS-PAGE of human GNAS stained with Coomassie Blue
Select
Wheat Germ Extract
GST
72.1 kDa
10 µg/$479; 25 µg/$670
Viewing 1-16 of 16 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).