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GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).
Gene Name: | GDP-mannose 4,6-dehydratase |
Synonyms: | GMDS, GDP-D-mannose dehydratase, GDP-mannose 4,6 dehydratase, GDP-mannose 4,6-dehydratase, GMD, SDR3E1 |
Target Sequences: | NP_001491.1 O60547 |
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