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GLUP / PACRG
PARK2 co-regulated
GLUP / PACRG is a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | PARK2 co-regulated |
| Synonyms: | PACRG, GLUP, HAK005771, PARK2 co-regulated, PARK2CRG, RP3-495O10.2, PARK2 coregulated gene protein |
| Target Sequences: | NP_689623.2 Q96M98 |
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