Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide, cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Isoform 3 seems to be inactive.
|Gene Name:||gamma-glutamyltransferase 1|
|Family/Subfamily:||Protease , Threonine T3|
|Synonyms:||GGT1, CD224 antigen, CD224, Ec 220.127.116.11, Glutamyl transpeptidase, GTG, Gamma-glutamyltransferase, Glutathione hydrolase 1, GLUTATHIONURIA, Gamma-glutamyl transpeptidase, Gamma-glutamyltransferase 1, Gamma-glutamyltranspeptidase 1, GGT, Leukotriene-C4 hydrolase, D22S672, D22S732, Gamma-glutamyltransferase 2, GGT 1|
|Target Sequences:||NM_005265 AAH25927.1 P19440|
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