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GGA3 is a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants have been identified in this gene.
Gene Name: | golgi-associated, gamma adaptin ear containing, ARF binding protein 3 |
Synonyms: | GGA3, KIAA0154 |
Target Sequences: | D63876 BAA09926.1 Q9NZ52 |
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