GFI1B

growth factor independent 1B transcription repressor

Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation.

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Products

Proteins (7)

Type

Over-Expression Lysate (4)

Recombinant (3)

Target

GFI1B (7)

Publications

No (7)

Tag

GST (1)

GST, N-terminus (1)

His, N-Terminal (1)

Myc-DDK (Flag) (4)

Species

Human (5)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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GFI1B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G125371

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

32.2 kDa

Price:

100 µg/$494

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Human GFI1B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87221

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

32.2 kDa

Price:

20 µg/$150

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Human GFI1B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87222

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37.3 kDa

Price:

20 µg/$150

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GFI1B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116816

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37.3 kDa

Price:

100 µg/$494

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Human GFI1B Protein (Recombinant His, N-Terminal) - LS-G144657

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

32.2 kDa

Price:

50 µg/$419

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Human GFI1B Protein (Recombinant GST) (Full Length) - LS-G31109

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

63.9 kDa

Price:

10 µg/$479; 25 µg/$670

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Human GFI1B Protein (Recombinant GST, N-terminus) (aa2-110) - LS-G60692

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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