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GDNF

glial cell derived neurotrophic factor

GDNF is a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene may be associated with Hirschsprung disease.

Gene Name: glial cell derived neurotrophic factor
Family/Subfamily: TGF beta , not assigned-TGF beta
Synonyms: GDNF, HSCR3, HFB1-GDNF, ATF, HGDNF
Target Sequences: NM_000514 NP_000505.1 P39905

☰ Filters
Products
Proteins (29)
Over-Expression Lysate (8)
Recombinant (21)
GDNF (29)
Animal-free (3)
No (29)
6His, C-terminus (1)
GST (1)
GST, N-terminus (1)
His (4)
His, N-Terminal (1)
His-SUMO (1)
Myc-DDK (Flag) (8)
Human (17)
Mouse (4)
Rat (3)
Rhesus monkey (1)
293T Cells (4)
CHO Cells (1)
E. coli (17)
HEK 293 Cells (4)
Human Cells (1)
Wheat Germ Extract (2)
Purified (10)
Low endotoxin level (13)
Biologically active (10)
Animal-free (3)
GDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
23.72 kDa
100 µg/$494
GDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
23.72 kDa
100 µg/$494
GDNF Protein
Select
E. coli
His-SUMO
31.1 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
GDNF Protein - 12.5% SDS-PAGE of human GDNF stained with Coomassie Blue
Select
Wheat Germ Extract
GST
50.1 kDa
2 µg/$439
Select
CHO Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
17-22 kDa (SDS-PAGE)
5 µg/$278; 25 µg/$381
Select
293T Cells
Myc-DDK (Flag)
23.72 kDa
20 µg/$150
GDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
23.72 kDa
20 µg/$150
GDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
18.8 kDa
20 µg/$150
GDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
14.6 kDa
20 µg/$150
GDNF Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
2 µg/$439
GDNF Protein
Select
E. coli
His, N-Terminal
17 kDa
10 µg/$265; 100 µg/$365; 250 µg/$518; 50 µg/$315; 500 µg/$949
GDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
18.8 kDa
100 µg/$494
GDNF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
14.6 kDa
100 µg/$494
Select
E. coli
None
Biologically active
30.1 kDa
10 µg/$388; 100 µg/$1,466; 500 µg/$3,025
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
15.1 kDa-30.2 kDa
2 µg/$268; 10 µg/$349
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
15.1 kDa-30.2 kDa
2 µg/$282; 10 µg/$370
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
15 kDa
2 µg/$268; 10 µg/$349
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
2 µg/$282; 10 µg/$370
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
15 kDa
2 µg/$268; 10 µg/$349
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
2 µg/$281; 10 µg/$369
Select
E. coli
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
17 kDa
1 mg/$2,653; 10 µg/$296; 50 µg/$478
Select
E. coli
102 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
11.33 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
15.1 kDa
20 µg/$360; 100 µg/$728
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
49.6kD
10 µg/$266; 50 µg/$339; 500 µg/$1,010; 1 mg/$1,329
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
15.1kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157
Viewing 1-25 of 29 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).