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GDF15

growth differentiation factor 15

Growth differentiation factor 15 (GDF15) is a protein belonging to the transforming growth factor beta superfamily that has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. GDF15 is also known as TGF-PL, MIC-1, PDF, PLAB, and PTGFB. GDF15 mRNA is most abundant in the liver, with lower levels seen in some other tissues. Its expression in liver can be significantly up-regulated in during injury of organs such as liver, kidney, heart and lung.

Gene Name: growth differentiation factor 15
Family/Subfamily: TGF beta , not assigned-TGF beta
Synonyms: GDF15, MIC1, MIC-1, NAG-1, NRG-1, NSAID-regulated gene 1 protein, PLAB, NSAID-activated gene 1 protein, Placental TGF-beta, PTGFB, GDF-15, PTGF-beta
Target Sequences: NM_004864 NP_004855.2 Q99988

Publications (1)

1
The myokine GDF-15 is a potential biomarker for myositis and associates with the protein aggregates of sporadic inclusion body myositis. Boel De Paepe, Fien Verhamme, Jan L De Bleecker. Cytokine. 2020 March;127:154966. [Full Text Article] [PubMed:31901761] Related Antibodies: LS-B2413.

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Proteins (11)
Over-Expression Lysate (2)
Recombinant (9)
GDF15 (11)
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GST (1)
His (4)
His, N-Terminal (2)
His-S (1)
Myc-DDK (Flag) (2)
Human (7)
Mouse (2)
Rat (1)
293T Cells (1)
CHO Cells (1)
E. coli (7)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Purified (2)
Low endotoxin level (2)
Biologically active (1)
GDF15 Protein - Recombinant Growth Differentiation Factor 15 By SDS-PAGE
Select
E. coli
His, N-Terminal
14.1 kDa
10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298
GDF15 Protein - Recombinant Growth Differentiation Factor 15 By SDS-PAGE
Select
E. coli
His, N-Terminal
34.9 kDa
10 µg/$289; 50 µg/$492; 200 µg/$982; 1 mg/$2,119; 5 mg/$3,431; 2 mg/$2,309
Select
CHO Cells
None
Biologically active
24.6 kDa
20 µg/$349; 5 µg/$268
GDF15 Protein
Select
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
GDF15 Protein - Recombinant Growth Differentiation Factor 15 By SDS-PAGE
Select
E. coli
His-S
17.2 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
GDF15 Protein - Recombinant Growth Differentiation Factor 15 By SDS-PAGE
Select
E. coli
His
14.0 kDa
10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309
GDF15 Protein - 12.5% SDS-PAGE of human GDF15 stained with Coomassie Blue
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Wheat Germ Extract
GST
56.21 kDa
2 µg/$439
GDF15 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
34 kDa
20 µg/$150
GDF15 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
34 kDa
100 µg/$494
Select
E. coli
270 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
30.69 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
GDF15 Protein
Select
E. coli
His
Less than 1.0 EU/µg protein (determined by LAL method).
100 µg/$511; 500 µg/$1,348; 20 µg/$311
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).