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GCKR

glucokinase (hexokinase 4) regulator

Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity.

Gene Name:	glucokinase (hexokinase 4) regulator
Synonyms:	GCKR, GKRP, FGQTL5, Glucokinase regulator, Glucokinase regulatory protein
Target Sequences:	NM_001486 NP_001477.2 Q14397

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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