GCK / Germinal Center Kinase

mitogen-activated protein kinase kinase kinase kinase 2

Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extend of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion.

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

GCK / Germinal Center Kinase (5)

Publications

No (5)

Tag

GST (1)

His-GST (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

Baculovirus (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

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Human GCK / Germinal Center Kinase Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68093

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

91.4 kDa

Price:

20 µg/$1,107

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Human GCK / Germinal Center Kinase Protein (Recombinant His-GST) (Met1-Tyr812) - LS-G97676

Source:

Baculovirus

Tag:

His-GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

119 kDa

Price:

50 µg/$707

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GCK / Germinal Center Kinase Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116548

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

91.4 kDa

Price:

100 µg/$710

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Human GCK / Germinal Center Kinase Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81426

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

91.4 kDa

Price:

20 µg/$215

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Human GCK / Germinal Center Kinase Protein (Recombinant GST) (Full Length) - LS-G30078

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

118 kDa

Price:

10 µg/$479; 25 µg/$670

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