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GCK / Germinal Center Kinase

mitogen-activated protein kinase kinase kinase kinase 2

Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extend of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion.

Gene Name: mitogen-activated protein kinase kinase kinase kinase 2
Family/Subfamily: Protein Kinase , KHS
Synonyms: MAP4K2, BL44, GC kinase, Rab8 interacting protein, RAB8IP, Rab8-interacting protein, Germinal center kinase, MEK kinase kinase 2, MEKKK 2
Target Sequences: NM_004579 NP_004570.2 Q12851

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Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
GCK / Germinal Center Kinase (5)
No (5)
GST (1)
His-GST (1)
Myc-DDK (Flag) (3)
Human (4)
293T Cells (1)
Baculovirus (1)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (2)
Low endotoxin level (1)
GCK / Germinal Center Kinase Protein - Purified recombinant protein MAP4K2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
91.4 kDa
20 µg/$1,107
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Baculovirus
His-GST
Less than 1.0 EU/µg protein (determined by LAL method).
119 kDa
50 µg/$707
GCK / Germinal Center Kinase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
91.4 kDa
100 µg/$710
GCK / Germinal Center Kinase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
91.4 kDa
20 µg/$215
GCK / Germinal Center Kinase Protein - 12.5% SDS-PAGE of human MAP4K2 stained with Coomassie Blue
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Wheat Germ Extract
GST
118 kDa
10 µg/$479; 25 µg/$670
Viewing 1-5 of 5 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).