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Lynnwood, WA 98036
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GCAT
glycine C-acetyltransferase
The degradation of L-threonine to glycine consists of a two-step biochemical pathway involving the enzymes L-threonine dehydrogenase and 2-amino-3-ketobutyrate coenzyme A ligase. L-Threonine is first converted into 2-amino-3-ketobutyrate by L-threonine dehydrogenase. This gene encodes the second enzyme in this pathway, which then catalyzes the reaction between 2-amino-3-ketobutyrate and coenzyme A to form glycine and acetyl-CoA. The encoded enzyme is considered a class II pyridoxal-phosphate-dependent aminotransferase. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 14.
| Gene Name: | glycine C-acetyltransferase |
| Synonyms: | GCAT, AKB ligase, Aminoacetone synthase, Glycine acetyltransferase, KBL, Glycine C-acetyltransferase |
| Target Sequences: | NM_014291 NP_055106.1 O75600 |
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