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GAX / MEOX2

mesenchyme homeobox 2

Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development (By similarity). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle.

Gene Name: mesenchyme homeobox 2
Synonyms: MEOX2, MOX2, Mesenchyme homeobox 2, GAX, Homeobox protein MOX-2
Target Sequences: NM_005924 NP_005915.2 P50222

Publications (1)

1
Transcription factor mesenchyme homeobox protein 2 (MEOX2) modulates nociceptor function. Tomislav Kokotovic, Ewelina M Lenartowicz, Michiel Langeslag, Cosmin I Ciotu, Christopher W Fell, Angelica Scaramuzza, Michael J M Fischer, Michaela Kress, Josef M Penninger, Vanja Nagy. The FEBS journal. 2022 June;289:3457-3476. [Full Text Article] [PubMed:35029322] [PMC:PMC9306780] Related Antibodies: LS-B5472.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).