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GAX / MEOX2
mesenchyme homeobox 2
Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development (By similarity). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle.
| Gene Name: | mesenchyme homeobox 2 |
| Synonyms: | MEOX2, MOX2, Mesenchyme homeobox 2, GAX, Homeobox protein MOX-2 |
| Target Sequences: | NM_005924 NP_005915.2 P50222 |
Publications (1)
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