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GAS41

YEATS domain containing 4

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.

Gene Name: YEATS domain containing 4
Synonyms: YEATS4, GAS41, Glioma-amplified sequence 41, Glioma-amplified sequence-41, NUBI-1, NuMA binding protein 1, NuMA-binding protein 1, NuBI1, YEATS domain containing 4, YAF9
Target Sequences: NM_006530 NP_006521.1 O95619

Publications (1)

1
Yeats4 drives ILC lineage commitment via activation of Lmo4 transcription. Benyu Liu , Liuliu Yang , Xiaoxiao Zhu , Huimu Li, Pingping Zhu, Jiayi Wu, Tiankun Lu, Luyun He, Nian Liu, Shu Meng, Liang Zhou, Buqing Ye, Yong Tian, Zusen Fan. The Journal of experimental medicine. 2019 Nov;216:2653-2668. [Full Text Article] [PubMed:31434684] [PMC:PMC6829595] Related Antibodies: LS-C155530.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).