GABBR1 / GABA B Receptor 1

gamma-aminobutyric acid (GABA) B receptor, 1

Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Calcium is required for high affinity binding to GABA. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Activated by (-)-baclofen, cgp27492 and blocked by phaclofen.Isoform 1E may regulate the formation of functional GABBR1/GABBR2 heterodimers by competing for GABBR2 binding. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

GABBR1 / GABA B Receptor 1 (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (2)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

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Purified (1)

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GABBR1 / GABA B Receptor 1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G110563

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

99.7 kDa

Price:

100 µg/$710

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Human GABBR1 / GABA B Receptor 1 Protein (Recombinant His-T7) (aa199-570) - LS-G25174

Source:

E. coli

Tag:

His-T7

Molecular Weight:

46.1 kDa

Price:

10 µg/$292; 50 µg/$512; 100 µg/$817; 200 µg/$1,018; 1 mg/$2,168; 500 µg/$1,690; 5 mg/$3,571; 2 mg/$2,359

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Human GABBR1 / GABA B Receptor 1 Protein (Recombinant GST, N-terminus) (aa52-151) - LS-G58631

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human GABBR1 / GABA B Receptor 1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82007

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

99.7 kDa

Price:

20 µg/$215

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Human GABBR1 / GABA B Receptor 1 Protein (Recombinant GST) (Full Length) - LS-G28545

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

121.5 kDa

Price:

2 µg/$439

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