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FYCO1 is a protein that contains a RUN domain, FYVE-type zinc finger domain and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P) and the autophagosome marker LC3. Mutations in this gene are a cause of autosomal recessive congenital cataract-2 (CATC2).
Gene Name: | FYVE And Coiled-coil Domain Containing 1 |
Synonyms: | FYCO1, CATC2, ZFYVE7 |
Target Sequences: | NM_024513 NP_078789.2 Q9BQS8 |
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