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FTH1 / Ferritin Heavy Chain

ferritin, heavy polypeptide 1

FTH1 / Ferritin Heavy Chain is the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined.

Gene Name: ferritin, heavy polypeptide 1
Synonyms: FTH1, Apoferritin, Ferritin H subunit, Ferritin heavy chain, Ferritin, heavy polypeptide 1, FHC, FTHL6, PIG15, PLIF, FTH
Target Sequences: NM_002032 NP_002023.2 P02794

Publications (10)

1
Ferritin contains less iron (59Fe) in cells when the protein pores are unfolded by mutation. Hasan MR, Tosha T, Theil EC. The Journal of biological chemistry. 2008 283:31394-400. [PubMed:18805796] [PMC:PMC2581568]
2
Redox control of iron regulatory protein 2 stability. Hausmann A, Lee J, Pantopoulos K. FEBS letters. 2011 585:687-92. [PubMed:21281640]
3
Alternative ferritin mRNA translation via internal initiation. Daba A, Koromilas AE, Pantopoulos K. RNA (New York, N.Y.). 2012 18:547-56. [PubMed:22271759] [PMC:PMC3285941]
4
Unregulated brain iron deposition in transgenic mice over-expressing HMOX1 in the astrocytic compartment. Song W, Zukor H, Lin SH, Liberman A, Tavitian A, Mui J, Vali H, Fillebeen C, Pantopoulos K, Wu TD, Guerquin-Kern JL, Schipper HM. Journal of neurochemistry. 2012 123:325-36. (WB; Mouse) [PubMed:22881289]
5
Iron deposition and ferritin heavy chain (Fth) localization in rodent teeth. Wen X, Paine ML. BMC research notes. 2013 6:1. (IHC-P; Mouse, Rat) [Full Text Article] [PubMed:23281703] [PMC:PMC3556315] Related Antibodies: LS-B5847.
6
Reabsorption of iron into acutely damaged rat liver: A role for ferritins. Malik IA, Wilting J, Ramadori G, Naz N. World journal of gastroenterology : WJG. 2017 November;23:7347-7358. (Human) [Full Text Article] [PubMed:29151689] [PMC:PMC5685841]
7
Ferritin in glioblastoma. Heidi Jaksch-Bogensperger , Sabine Spiegl-Kreinecker, Paolo Arosio, Peter Eckl, Stefan Golaszewski, Yvonne Ebner, Rahman Al-Schameri, Peter Strasser, Serge Weis , Nikolaus Bresgen. British journal of cancer. 2020 May;122:1441-1444. [Full Text Article] [PubMed:32203223] [PMC:PMC7217840]
8
Co-targeting BET bromodomain BRD4 and RAC1 suppresses growth, stemness and tumorigenesis by disrupting the c-MYC-G9a-FTH1axis and downregulating HDAC1 in molecular subtypes of breast cancer. Amjad Ali, Jasmin Shafarin, Hema Unnikannan, Nour Al-Jabi, Rola Abu Jabal, Khuloud Bajbouj, Jibran Sualeh Muhammad, Mawieh Hamad. International journal of biological sciences. 2021 November;17:4474-4492. [Full Text Article] [PubMed:34803511] [PMC:PMC8579449] Related Antibodies: LS-B11085.
9
Unbalance in Iron Metabolism in Childhood Leukemia Converges with Treatment Intensity: Biochemical and Clinical Analysis. Monika Lecka, Artur Slomka, Katarzyna Albrecht, Ewa Zekanowska, Michal Romiszewski, Jan Styczynski. Cancers. 2021 June;13:3029. [Full Text Article] [PubMed:34204310] [PMC:PMC8233795]
10
ATG7 is essential for secretion of iron from ameloblasts and normal growth of murine incisors during aging. Supawadee Sukseree, Uwe Yacine Schwarze, Reinhard Gruber, Florian Gruber, Maria Quiles Del Rey, Joseph D Mancias, John D Bartlett, Erwin Tschachler, Leopold Eckhart. Autophagy. 2020 October;16:1851-1857. [Full Text Article] [PubMed:31880208] [PMC:PMC8386597] Related Antibodies: LS-B5847.
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).