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FTCD / 58K Golgi Protein

formimidoyltransferase cyclodeaminase

Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.Binds and promotes bundling of vimentin filaments originating from the Golgi.

Gene Name:	formimidoyltransferase cyclodeaminase
Synonyms:	FTCD, 58K Golgi Protein, LCHC1
Target Sequences:	NM_006657 NP_006648.1 O95954

Publications (8)

A novel 58-kDa protein associates with the Golgi apparatus and microtubules. Bloom GS, Brashear TA. The Journal of biological chemistry. 1989 264:16083-92. (ICC, WB; Rat) [PubMed:2777777]

Kinesin is the motor for microtubule-mediated Golgi-to-ER membrane traffic. Lippincott-Schwartz J, Cole NB, Marotta A, Conrad PA, Bloom GS. The Journal of cell biology. 1995 128:293-306. [PubMed:7844144] [PMC:PMC2120357]

A formiminotransferase cyclodeaminase isoform is localized to the Golgi complex and can mediate interaction of trans-Golgi network-derived vesicles with microtubules. Hennig D, Scales SJ, Moreau A, Murley LL, De Mey J, Kreis TE. The Journal of biological chemistry. 1998 273:19602-11. (ICC) [PubMed:9677386]

58K, a microtubule-binding Golgi protein, is a formiminotransferase cyclodeaminase. Bashour AM, Bloom GS. The Journal of biological chemistry. 1998 273:19612-7. (WB; Rat) [PubMed:9677387]

Molecular cloning, characterization, and dynamics of rat formiminotransferase cyclodeaminase, a Golgi-associated 58-kDa protein. Gao YS, Alvarez C, Nelson DS, Sztul E. The Journal of biological chemistry. 1998 273:33825-34. (ICC, WB) [PubMed:9837973]

A Bpag1 isoform involved in cytoskeletal organization surrounding the nucleus. Young KG, Pinheiro B, Kothary R. Experimental cell research. 2006 312:121-34. [PubMed:16289082]

Mutation in the DC-SIGN cytoplasmic triacidic cluster motif markedly attenuates receptor activity for phagocytosis and endocytosis of mannose-containing ligands by human myeloid cells. Azad AK, Torrelles JB, Schlesinger LS. Journal of leukocyte biology. 2008 84:1594-603. [PubMed:18772280] [PMC:PMC2614595]

Differential effects of exogenous and autocrine growth hormone on LNCaP prostate cancer cell proliferation and survival. Gittenberger-de Groot AC, Mahtab EA, Hahurij ND, Wisse LJ, Deruiter MC, Wijffels MC, Poelmann RE. Journal of cellular biochemistry. 2012 (ICC; Human) [PubMed:23238889]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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