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FST / Follistatin

follistatin

Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin.

Gene Name: follistatin
Synonyms: FST, Activin-binding protein, Follistatin isoform FST317, Follistatin, Fs
Target Sequences: NM_006350 NP_006341.1 P19883

Publications (4)

1
Follistatin is a novel therapeutic target and biomarker in FLT3/ITD acute myeloid leukemia. Bai-Liang He , Ning Yang , Cheuk Him Man, Nelson Ka-Lam Ng, Chae-Yin Cher, Ho-Ching Leung, Leo Lai-Hok Kan, Bowie Yik-Ling Cheng, Stephen Sze-Yuen Lam, Michelle Lu-Lu Wang, Chun-Xiao Zhang, Hin Kwok, Grace Cheng, Rakesh Sharma, Alvin Chun-Hang Ma, Chi Wai Eric So, Yok-Lam Kwong, Anskar Yu-Hung Leung. EMBO molecular medicine. 2020 Apr;12:e10895. [Full Text Article] [PubMed:32134197] [PMC:PMC7136967]
2
Follistatin-induced muscle hypertrophy in aged mice improves neuromuscular junction innervation and function. Chitra C Iyer, Deepti Chugh, Prameela J Bobbili, Anton J Blatnik Iii, Alexander E Crum, Allen F Yi, Brian K Kaspar, Kathrin C Meyer, Arthur H M Burghes, W David Arnold. Neurobiology of aging. 2021 August;104:32-41. [Full Text Article] [PubMed:33964607] [PMC:PMC8225567]
3
Detection of black market follistatin 344. Christian Reichel, Günter Gmeiner, Mario Thevis. Drug testing and analysis. 2020 October;12:1522-1533. [Full Text Article] [PubMed:33460286]
4
Detection of black market follistatin 344. Christian Reichel, Günter Gmeiner, Mario Thevis. Drug testing and analysis. 2019 November;11:1675-1697. [Full Text Article] [PubMed:31758732]
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).