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FSP27 / CIDEC

cell death-inducing DFFA-like effector c

Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair. Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1. May act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH. When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment. As mature adipocytes, that express high CIDEC levels, are quite resistant to apoptotic stimuli, the physiological significance of its role in apoptosis is unclear. May play a role in the modulation of the response to osmotic stress by preventing NFAT5 to translocate into the nucleus and activate its target genes expression.

Gene Name: cell death-inducing DFFA-like effector c
Synonyms: CIDEC, CIDE3, CIDE-3, FSP27, Cell death activator CIDE-3, CIDEX, Fat specific protein 27
Target Sequences: NM_022094 NP_071377.2 Q96AQ7

Publications (2)

1
Microarray analysis of hepatic gene expression identifies new genes involved in steatotic liver. Guilln N, Navarro MA, Arnal C, Noone E, Arbons-Mainar JM, Acn S, Surra JC, Muniesa P, Roche HM, Osada J. Physiological genomics. 2009 37:187-98. [PubMed:19258494] [PMC:PMC2685506]
2
Excess dietary iodine differentially affects thyroid gene expression in diabetes, thyroiditis-prone versus -resistant BioBreeding (BB) rats. Swist E, Chen Q, Qiao C, Caldwell D, Gruber H, Scoggan KA. Molecular nutrition & food research. 2011 55:1875-86. (WB; Rat) [PubMed:22058052]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).