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FOXR1 encodes a member of the forkhead box (FOX) family of transcription factors. FOX family members are monomeric, helix-turn-helix proteins with a core DNA-binding domain of approximately 110 aa. Many FOX transcription factors play roles in determining cell fates during early development. This forkhead box protein lacks the C-terminal basic region found in many other FOX family members. It is located within the 11q23.3 region which is commonly deleted in neuroblastomas.
Gene Name: | forkhead box R1 |
Synonyms: | FOXR1, Forkhead box protein R1, FOXN5, Forkhead box R1, Forkhead box R1 variant 1, DLNB13, Forkhead box protein N5 |
Target Sequences: | NM_181721 NP_859072.1 Q6PIV2 |
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