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FOXA2
forkhead box A2
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
| Gene Name: | forkhead box A2 |
| Family/Subfamily: | Transcription factor , not assigned-Transcription factor |
| Synonyms: | FOXA2, HNF3B, HNF-3-beta, HNF-3B, TCF3B, Transcription factor 3B, Forkhead box A2, Forkhead box protein A2, Hepatic nuclear factor-3-beta, TCF-3B |
| Target Sequences: | NM_021784 NP_068556.2 Q9Y261 |
Publications (5)
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