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FOLR1 / Folate Receptor Alpha

folate receptor 1 (adult)

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation.

Gene Name:	folate receptor 1 (adult)
Synonyms:	FOLR1, Adult folate-binding protein, FBP, Folate receptor alpha, KB cells FBP, Folate binding protein, Folate receptor 1, Folate receptor 1 (adult), Folate receptor, adult, FOLR, FR-alpha
Target Sequences:	NM_016730 NP_057942.1 P15328

Publications (6)

A folate receptor-targeted lipoplex delivering interleukin-15 gene for colon cancer immunotherapy. Liang X, Luo M, Wei XW, Ma CC, Yang YH, Shao B, Liu YT, Liu T, Ren J, Liu L, He ZY, Wei YQ. Oncotarget. 2016 7:52207-52217. (Flo; Mouse) [Full Text Article] [PubMed:27438147] [PMC:PMC5239545] Related Antibodies: LS-B5727.

Expression status of folate receptor alpha is a predictor of survival in pancreatic ductal adenocarcinoma. Cai L, Michelakos T, Ferrone CR, Zhang L, Deshpande V, Shen Q, DeLeo A, Yamada T, Zhang G, Ferrone S, Wang X. Oncotarget. 2017 8:37646-37656. (IHC, Flo; Human) [Full Text Article] [PubMed:28430580] [PMC:PMC5514937] Related Antibodies: LS-B5727, LS-C129132.

Intraoperative near-infrared fluorescence imaging targeting folate receptors identifies lung cancer in a large-animal model. Keating JJ, Runge JJ, Singhal S, Nims S, Venegas O, Durham AC, Swain G, Nie S, Low PS, Holt DE. Cancer. 2017 May;123:1051-1060. [Full Text Article] [PubMed:28263385] [PMC:PMC5341137] Related Antibodies: LS-B5727.

Expression of inhibitory receptors on intratumoral T cells modulates the activity of a T cell-bispecific antibody targeting folate receptor. Schreiner J, Thommen DS, Herzig P, Bacac M, Klein C, Roller A, Belousov A, Levitsky V, Savic S, Moersig W, Uhlenbrock F, Heinzelmann-Schwarz VA, Umana P, Pisa P, von Bergwelt-Baildon M, Lardinois D, Müller P, Karanikas V, Zippelius A. Oncoimmunology. 2015 June;5:e1062969. [Full Text Article] [PubMed:27057429] [PMC:PMC4801463] Related Antibodies: LS-C129132.

Folate receptor-mediated boron-10 containing carbon nanoparticles as potential delivery vehicles for boron neutron capture therapy of nonfunctional pituitary adenomas. Dai C, Cai F, Hwang KC, Zhou Y, Zhang Z, Liu X, Ma S, Yang Y, Yao Y, Feng M, Bao X, Li G, Wei J, Jiao Y, Wei Z, Ma W, Wang R. Science China. Life sciences. 2013 February;56:163-173. [Full Text Article] [PubMed:23334699]

Folate Receptor Overexpression in Human and Canine Meningiomas-Immunohistochemistry and Case Report of Intraoperative Molecular Imaging. John T Pierce, Steve S Cho, Shayoni Nag, Ryan Zeh, Jun Jeon, David Holt, Amy Durham, MacLean P Nasrallah, Sunil Singhal, John Y K Lee. Neurosurgery. 2018 August; [Full Text Article] [PubMed:30113687] [PMC:PMC6904722] Related Antibodies: LS-B5727.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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