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FMOD / Fibromodulin

fibromodulin

Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants.

Gene Name: fibromodulin
Synonyms: FMOD, Fibromodulin, Fibromodulin proteoglycan, FM, KSPG fibromodulin, SLRR2E
Target Sequences: NM_002023 NP_002014.2 Q06828

Publications (2)

1
Anchored Fibromodulin as a Novel Target in Chronic Lymphocytic Leukemia: Diagnostic and Therapeutic Implications. Lia Farahi, Fatemeh Ghaemimanesh, Saeideh Milani, Seyed Mohsen Razavi, Reza Hadavi, Ali Ahmad Bayat, Ali Salimi, Mohammad Mehdi Akhondi, Hodjattallah Rabbani. Iranian journal of immunology. 2019 June;16:127-141. [Full Text Article] [PubMed:31182687] Related Antibodies: LS-C677960.
2
The secretome atlas of two mouse models of progeria. Diego Quintana-Torres, Alejandra Valle-Cao, Pablo Bousquets-Muñoz, Sandra Freitas-Rodríguez, Francisco Rodríguez, Alejandro Lucia, Carlos López-Otín, Alejandro López-Soto, Alicia R Folgueras. Aging cell. 2023 October;22:e13952. [Full Text Article] [PubMed:37565451] [PMC:PMC10465940]

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Proteins (6)
Over-Expression Lysate (2)
Recombinant (4)
FMOD / Fibromodulin (6)
No (6)
GST (1)
His (1)
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Myc-DDK (Flag) (3)
Human (4)
Rat (1)
293T Cells (1)
E. coli (2)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (1)
FMOD / Fibromodulin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
43.18 kDa
100 µg/$494
FMOD / Fibromodulin Protein - Recombinant Fibromodulin By SDS-PAGE
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E. coli
His-T7
45.0 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
FMOD / Fibromodulin Protein - Recombinant Fibromodulin By SDS-PAGE
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E. coli
His
45.0 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
FMOD / Fibromodulin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
43.18 kDa
20 µg/$150
FMOD / Fibromodulin Protein - Purified recombinant protein FMOD was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
41.2 kDa
20 µg/$1,107
FMOD / Fibromodulin Protein - 12.5% SDS-PAGE of human FMOD stained with Coomassie Blue
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Wheat Germ Extract
GST
67.1 kDa
2 µg/$439
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).