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FLVCR / FLVCR1

feline leukemia virus subgroup C cellular receptor 1

Isoform 1: Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and may be required to protect developing erythroid cells from heme toxicity. Heme export also provides protection from heme or ferrous iron toxicities in liver and brain. Causes susceptibility to FeLV-C in vitro. Required during erythtopoiesis to maintain intracellular free heme balance since in proerythroblasts, heme synthesis intensifies and it's accumulation is toxic for cells.Isoform 2: Heme transporter that promotes heme efflux from the mitochondrion to the cytoplasm. Essential for erythroid differentiation.

Gene Name: feline leukemia virus subgroup C cellular receptor 1
Synonyms: FLVCR1, PCA, PCARP, AXPC1, FLVCR, HFLVCR, MFSD7B
Target Sequences: NM_014053 NP_054772.1 Q9Y5Y0

Publications (1)

1
New Insights into the Pivotal Role of Iron/Heme Metabolism in TLR4/NF-?B Signaling-Mediated Inflammatory Responses in Human Monocytes. Dong Young Kang, Nipin Sp, Eun Seong Jo, Jin-Moo Lee, Kyoung-Jin Jang. Cells. 2021 September;10:2549. [Full Text Article] [PubMed:34685529] [PMC:PMC8534183] Related Antibodies: LS-C750126.

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Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
FLVCR / FLVCR1 (4)
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GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (2)
Human (3)
293T Cells (1)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Purified (1)
FLVCR / FLVCR1 Protein - 12.5% SDS-PAGE of human FLVCR stained with Coomassie Blue
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Wheat Germ Extract
GST
86.3 kDa
10 µg/$479; 25 µg/$670
FLVCR / FLVCR1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
FLVCR / FLVCR1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
59.7 kDa
20 µg/$150
FLVCR / FLVCR1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
59.7 kDa
100 µg/$494
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).