FLT4 / VEGFR3

fms-related tyrosine kinase 4

Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.

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Products

ELISA Kits (28)

Type

Custom (2)

Sandwich (24)

Sandwich CLIA (2)

Target

FLT4 / VEGFR3 (28)

Reactivity

Human (12)

Mouse (6)

Rat (6)

Chicken (1)

Monkey (1)

Porcine (1)

Rabbit (1)

Format

12 x 8-Well Microstrips (3)

96-Well Microplate (4)

96-Well Strip Plate (20)

Publications

No (28)

Sample Type

Cell Culture Supernatants (6)

Cell Lysates (1)

EDTA Plasma (1)

Heparin Plasma (1)

Plasma (19)

Serum (23)

Tissue Homogenates (8)

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Mouse FLT4 / VEGFR3 (CLIA) ELISA Kit - LS-F31016

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse

Range:

15.63 - 1000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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Rat FLT4 / VEGFR3 (Sandwich ELISA) ELISA Kit - LS-F35540

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Human FLT4 / VEGFR3 (CLIA) ELISA Kit - LS-F30251

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

31.25 - 2000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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Mouse FLT4 / VEGFR3 (Custom ELISA) ELISA Kit - LS-F13859

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Mouse FLT4 / VEGFR3 (Sandwich ELISA) ELISA Kit - LS-F23867

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Human FLT4 / VEGFR3 (Sandwich ELISA) ELISA Kit - LS-F21222

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Human FLT4 / VEGFR3 (Sandwich ELISA) ELISA Kit - LS-F24705

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

156 - 10000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$717

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Human FLT4 / VEGFR3 (Sandwich ELISA) ELISA Kit - LS-F27309

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

2.5 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$913

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Rat FLT4 / VEGFR3 (Sandwich ELISA) ELISA Kit - LS-F27619

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

100 - 2500 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$913

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Rat FLT4 / VEGFR3 (Sandwich ELISA) ELISA Kit - LS-F31519

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

156 - 10000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Serum

Price:

1 Plate/$717

Select

Mouse FLT4 / VEGFR3 (Sandwich ELISA) ELISA Kit - LS-F31490

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

156 - 10000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Serum

Price:

1 Plate/$717

Select

Human FLT4 / VEGFR3 (Sandwich ELISA) ELISA Kit - LS-F35539

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human FLT4 / VEGFR3 (Sandwich ELISA) ELISA Kit - LS-F54822

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$870

Select

Chicken FLT4 / VEGFR3 (Sandwich ELISA) ELISA Kit - LS-F49008

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

Select

Monkey FLT4 / VEGFR3 (Sandwich ELISA) ELISA Kit - LS-F49009

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

Select

Rabbit FLT4 / VEGFR3 (Sandwich ELISA) ELISA Kit - LS-F49011

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

Select

Porcine FLT4 / VEGFR3 (Sandwich ELISA) ELISA Kit - LS-F49010

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Porcine

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

Select

Mouse FLT4 / VEGFR3 (Sandwich ELISA) ELISA Kit - LS-F55892

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human FLT4 / VEGFR3 (Sandwich ELISA) ELISA Kit - LS-F55573

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

15.6 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$866

Select

Mouse FLT4 / VEGFR3 (Custom ELISA) ELISA Kit - LS-F57024

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

9.38 - 600 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$870

Select

Human FLT4 / VEGFR3 (Sandwich ELISA) ELISA Kit - LS-F57249

Type:

Sandwich

Reactivity:

Human

Range:

156 - 10000 pg/ml

Sample Types:

Cell Culture Supernatants, EDTA Plasma, Heparin Plasma, Serum

Price:

1 Plate/$795

Select

Rat FLT4 / VEGFR3 (Sandwich ELISA) ELISA Kit - LS-F6803

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$856

Select

Human FLT4 / VEGFR3 (Sandwich ELISA) ELISA Kit - LS-F5063

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$798

Select

Rat FLT4 / VEGFR3 (Sandwich ELISA) ELISA Kit - LS-F10507

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Rat

Range:

156 - 10000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Serum

Price:

1 Plate/$795

Select

Rat FLT4 / VEGFR3 (Sandwich ELISA) ELISA Kit - LS-F12948

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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