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FIS1

fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)

Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.

Gene Name:	fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
Synonyms:	FIS1, CGI-135, FIS1 homolog, HFis1, TPR repeat protein 11, TTC11, H_NH0132A01.6
Target Sequences:	NM_016068 NP_057152.2 Q9Y3D6

Publications (1)

Proteomic Profiling Revealed Mitochondrial Dysfunction in Photoreceptor Cells under Hyperglycemia. Christie Hang-I Lam, Jimmy Ka-Wai Cheung, Dennis Yan-Yin Tse, Thomas Chuen Lam. International journal of molecular sciences. 2022 November;23: [Full Text Article] [PubMed:36362154] [PMC:PMC9658613] Related Antibodies: LS-C404988.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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