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Fibulin-3 / EFEMP1

EGF containing fibulin-like extracellular matrix protein 1

Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.

Gene Name: EGF containing fibulin-like extracellular matrix protein 1
Synonyms: EFEMP1, DHRD, Extracellular protein S1-5, FBNL, FBLN3, Fibrillin-like protein, Fibrillin-like, MLVT, S1-5, MTLV, DRAD, FIBL-3, Fibulin-3
Target Sequences: NM_004105 NP_004096.2 Q12805

Publications (2)

1
Transcriptional heterogeneity of fibroblasts is a hallmark of the aging heart. Ramon Vidal, Julian Uwe Gabriel Wagner, Caroline Braeuning, Cornelius Fischer, Ralph Patrick, Lukas Tombor, Marion Muhly-Reinholz, David John, Magdalena Kliem, Thomas Conrad, Nuno Guimarães-Camboa, Richard Harvey, Stefanie Dimmeler, Sascha Sauer. JCI insight. 2019 Nov;4:e131092. [Full Text Article] [PubMed:31723062] [PMC:PMC6948853] Related Antibodies: LS-B11500.
2
Utility of EFEMP1 in the Prediction of Oncologic Outcomes of Urothelial Carcinoma10<sup> Department of Pathology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung 801, Taiwan12<sup> Department of Urology, Ministry of Health and Welfare, Pingtung Hospital, Pingtung 900, Taiwan. Tzu-Ju Chen , Ti-Chun Chan , Wan-Shan Li , Chien-Feng Li , Hung-Lung Ke , Yu-Ching Wei , Wen-Jeng Wu , Wei-Ming Li. Genes. 2021 Jun;12:872. [Full Text Article] [PubMed:34204134] [PMC:PMC8226762] Related Antibodies: LS-C167641.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).