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FHL2 is a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Gene Name: | four and a half LIM domains 2 |
Synonyms: | FHL2, Aging-associated gene 11, DRAL, AAG11, Four and a half LIM domains 2, FHL-2, LIM domain protein DRAL, Skeletal muscle lim-protein 2, SLIM-3, SLIM3, Four-and-a-half LIM domains 2, Skeletal muscle LIM-protein 3 |
Target Sequences: | NP_001034581.1 Q14192 |
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