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FHIT

fragile histidine triad

Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca2+ transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor.

Gene Name: fragile histidine triad
Synonyms: FHIT, AP3Aase, Dinucleosidetriphosphatase, Fragile histidine triad, Fragile histidine triad gene, AP3A hydrolase, Bis(5-adenosyl)-triphosphatase, FRA3B, Tumor suppressor protein
Target Sequences: NM_002012 NP_002003.1 P49789

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Products
Proteins (10)
Over-Expression Lysate (4)
Recombinant (6)
FHIT (10)
No (10)
6His, N-terminus (2)
GST, N-terminus (1)
His (1)
Myc-DDK (Flag) (6)
Human (7)
Mouse (1)
293T Cells (2)
E. coli (2)
HEK 293 Cells (4)
Wheat Germ Extract (1)
Yeast (1)
Purified (1)
FHIT Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
16.7 kDa
100 µg/$494
FHIT Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
16.7 kDa
100 µg/$494
FHIT Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
16.7 kDa
20 µg/$150
FHIT Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
16.7 kDa
20 µg/$150
FHIT Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
FHIT Protein - Purified recombinant protein FHIT was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
16.7 kDa
20 µg/$1,107
FHIT Protein - Purified recombinant protein FHIT was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
16.7 kDa
20 µg/$1,107
FHIT Protein
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E. coli
6His, N-terminus
19 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365; 500 µg/$949
FHIT Protein
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E. coli
His
100 µg/$342; 500 µg/$641; 20 µg/$254
FHIT Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Yeast
6His, N-terminus
100 µg/$499; 20 µg/$364; 1 mg/$1,683
Viewing 1-10 of 10 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).