FGR

feline Gardner-Rasheed sarcoma viral oncogene homolog

Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1.

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Products

Proteins (9)

Type

Over-Expression Lysate (6)

Recombinant (3)

Target

FGR (9)

Publications

No (9)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (7)

Species

Human (6)

Source

293T Cells (3)

HEK 293 Cells (4)

Wheat Germ Extract (2)

Purification

Purified (1)

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FGR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G119411

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.3 kDa

Price:

100 µg/$494

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FGR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G119413

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.3 kDa

Price:

100 µg/$710

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Human FGR Protein (Recombinant GST) (Full Length) - LS-G28472

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

85.9 kDa

Price:

10 µg/$479; 25 µg/$670

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Human FGR Protein (Recombinant GST, N-terminus) (aa1-90) - LS-G58566

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human FGR Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66753

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.3 kDa

Price:

20 µg/$1,107

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Human FGR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78435

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.3 kDa

Price:

20 µg/$215

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Human FGR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78436

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.3 kDa

Price:

20 µg/$150

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Human FGR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78439

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.3 kDa

Price:

20 µg/$150

Select

FGR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100496

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.3 kDa

Price:

100 µg/$494

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