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FGFR2 / FGF Receptor 2

fibroblast growth factor receptor 2

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.

Gene Name: fibroblast growth factor receptor 2
Family/Subfamily: Protein Kinase , FGF Receptor
Synonyms: FGFR2, BEK, BBDS, Bacteria-expressed kinase, CD332 antigen, CFD1, Craniofacial dysostosis 1, CEK3, Fgf bek, FGF receptor, Hydroxyaryl-protein kinase, Jackson-Weiss syndrome, JWS, FGF Receptor 2, KSAM, KGFR, Soluble FGFR4 variant 4, BFR-1, TK14, TK25, CD332, ECT1, K-SAM
Target Sequences: NM_000141 NP_000132.3 P21802

Publications (2)

1
The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis. Gao Q, Zhang J, Wang X, Liu Y, He R, Liu X, Wang F, Feng J, Yang D, Wang Z, Meng A, Yan X. Nature communications. 2017 8:15279. (WB; Human) [Full Text Article] [PubMed:28589943] [PMC:PMC5467231] Related Antibodies: LS-C97522.
2
A kinase-independent role for EGF receptor in autophagy initiation. Tan X, Thapa N, Sun Y, Anderson RA. Cell. Jan;160:145-60. [Full Text Article] [PubMed:25594178] [PMC:PMC4297316] Related Antibodies: LS-C172910.

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cDNAs (26)
cDNA Clone (2)
Expression-Ready ORF Clone (24)
FGFR2 / FGF Receptor 2 (26)
No (26)
DDK (Flag), C-terminus (2)
DDK (Flag), N-terminus (2)
GFP, C-terminus (4)
HA, C-terminus (2)
HA, N-terminus (2)
His, C-terminus (2)
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Human (13)
Mouse (13)
Lentiviral (2)
Mammalian (22)
FGFR2 / FGF Receptor 2 NucleicAcid
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pMD18-T Simple
Untagged
1 Each/$75
FGFR2 / FGF Receptor 2 NucleicAcid
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Mammalian
pCMV3-Untagged
Untagged
1 Each/$216
FGFR2 / FGF Receptor 2 NucleicAcid
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Mammalian
pCMV3-C-DDK (Flag)
DDK (Flag), C-terminus
1 Each/$216
FGFR2 / FGF Receptor 2 NucleicAcid
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Mammalian
pCMV3-C-GFP
GFP, C-terminus
1 Each/$245
FGFR2 / FGF Receptor 2 NucleicAcid
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Mammalian
pCMV3-C-HA
HA, C-terminus
1 Each/$216
FGFR2 / FGF Receptor 2 NucleicAcid
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Mammalian
pCMV3-C-His
His, C-terminus
1 Each/$216
FGFR2 / FGF Receptor 2 NucleicAcid
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Mammalian
pCMV3-C-Myc
Myc, C-terminus
1 Each/$216
FGFR2 / FGF Receptor 2 NucleicAcid
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Mammalian
pCMV3-C-OFP
OFP, C-terminus
1 Each/$245
FGFR2 / FGF Receptor 2 NucleicAcid
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Mammalian
pCMV3-N-DDK (Flag)
DDK (Flag), N-terminus
1 Each/$216
FGFR2 / FGF Receptor 2 NucleicAcid
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Mammalian
pCMV3-N-HA
HA, N-terminus
1 Each/$216
FGFR2 / FGF Receptor 2 NucleicAcid
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Mammalian
pCMV3-N-His
His, N-terminus
1 Each/$216
FGFR2 / FGF Receptor 2 NucleicAcid
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Mammalian
pCMV3-N-Myc
Myc, N-terminus
1 Each/$216
FGFR2 / FGF Receptor 2 NucleicAcid
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Lentiviral
pLV-C-GFP
GFP, C-terminus
1 Each/$576
FGFR2 / FGF Receptor 2 NucleicAcid
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Mammalian
pCMV3-Untagged
Untagged
1 Each/$216
FGFR2 / FGF Receptor 2 NucleicAcid
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Mammalian
pCMV3-C-DDK (Flag)
DDK (Flag), C-terminus
1 Each/$216
FGFR2 / FGF Receptor 2 NucleicAcid
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Mammalian
pCMV3-C-GFP
GFP, C-terminus
1 Each/$245
FGFR2 / FGF Receptor 2 NucleicAcid
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Mammalian
pCMV3-C-HA
HA, C-terminus
1 Each/$216
FGFR2 / FGF Receptor 2 NucleicAcid
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Mammalian
pCMV3-C-His
His, C-terminus
1 Each/$216
FGFR2 / FGF Receptor 2 NucleicAcid
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Mammalian
pCMV3-C-Myc
Myc, C-terminus
1 Each/$216
FGFR2 / FGF Receptor 2 NucleicAcid
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Mammalian
pCMV3-C-OFP
OFP, C-terminus
1 Each/$245
FGFR2 / FGF Receptor 2 NucleicAcid
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Mammalian
pCMV3-SP-N-DDK (Flag)
DDK (Flag), N-terminus
1 Each/$216
FGFR2 / FGF Receptor 2 NucleicAcid
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Mammalian
pCMV3-SP-N-HA
HA, N-terminus
1 Each/$216
FGFR2 / FGF Receptor 2 NucleicAcid
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Mammalian
pCMV3-SP-N-His
His, N-terminus
1 Each/$216
FGFR2 / FGF Receptor 2 NucleicAcid
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Mammalian
pCMV3-SP-N-Myc
Myc, N-terminus
1 Each/$216
FGFR2 / FGF Receptor 2 NucleicAcid
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Lentiviral
pLV-C-GFP
GFP, C-terminus
1 Each/$576
Viewing 1-25 of 26 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).