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FERMT1 / Kindlin
fermitin family member 1
Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression.
| Gene Name: | fermitin family member 1 |
| Synonyms: | FERMT1, C20orf42, DTGCU2, Fermitin family homolog 1, Kindlin syndrome protein, KIND1, Kindlin 1, UNC112A, URP1, UNC112 related protein 1, Fermitin family member 1, Kindlerin, Kindlin, Kindlin-1, Unc-112-related protein 1 |
| Target Sequences: | NM_017671 NP_060141.3 Q9BQL6 |
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