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FE65L1 / APBB2 interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants.
Gene Name: | amyloid beta (A4) precursor protein-binding, family B, member 2 |
Synonyms: | APBB2, Fe65-like 1, FE65L1, Fe65-like, FE65L, Protein Fe65-like 1 |
Target Sequences: | U62325 AAC50805.1 Q92870 |
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