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FCRL3 encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus.
Gene Name: | Fc receptor-like 3 |
Synonyms: | FCRL3, CD307c, CD307c antigen, Fc receptor-like protein 3, FcR-like protein 3, IFGP family protein 3, IFGP3, IRTA3, Fc receptor homolog 3, FCRH3, SPAP2, SPAP2a, SPAP2c, SPAP2d, SPAP2e, Fc receptor-like 3, HIFGP3, SPAP2b |
Target Sequences: | NM_052939 NP_443171.2 Q96P31 |
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