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FBXL7 is a member of the F-box protein family which is characterized by a 42-48 amino acid motif, the F-box, which binds to the S-phase kinase-associated protein 1 (Skp1) protein. The F-box proteins constitute one of the four subunits of E3 ubiquitin protein ligases called SCFs (SKP1-Cul1-F-box), which play a role in phosphorylation-dependent ubiquitination of proteins. The F-box proteins are divided into 3 subfamilies based on the other domain in the protein: F-box proteins that also have a WD-40 domain (Fbws subfamily), F-box proteins that also have leucine-rich repeats (Fbls subfamily) and F-box proteins that contain other motifs or lack known protein-interaction domains (Fbxs subfamily). The protein encoded by this gene belongs to the Fbls subfamily. Alternative splicing results in multiple transcript variants of this gene.
Gene Name: | F-box and leucine-rich repeat protein 7 |
Family/Subfamily: | F-Box |
Synonyms: | FBXL7, FBL6, F-box protein Fbl7, F-box/LRR-repeat protein 7, F-box protein FBL6/FBL7, FBL7, KIAA0840 |
Target Sequences: | NM_012304 NP_036436.1 Q9UJT9 |
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