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Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion.
Gene Name: | FERM, RhoGEF and pleckstrin domain protein 2 |
Synonyms: | FARP2, FRG, FGD1-related Cdc42-GEF, PLEKHC3, KIAA0793, FERM domain including RhoGEF, FIR |
Target Sequences: | NM_014808 O94887 O94887 |
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