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FAM134B is a cis-Golgi transmembrane protein that may be necessary for the long-term survival of nociceptive and autonomic ganglion neurons. Mutations in this gene are a cause of hereditary sensory and autonomic neuropathy type IIB (HSAN IIB), and this gene may also play a role in susceptibility to vascular dementia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Gene Name: | family with sequence similarity 134, member B |
Synonyms: | FAM134B, HSAN2B, JK1, JK-1, Protein FAM134B |
Target Sequences: | NM_019000 NP_061873.2 Q9H6L5 |
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