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The protein encoded by this gene is a member of the GDSL/SGNH superfamily. Members of this family are hydrolytic enzymes with esterase and lipase activity and broad substrate specificity. This protein belongs to the Pmr5-Cas1p-esterase subfamily in that it contains the catalytic triad comprised of serine, aspartate and histidine and lacks two conserved regions (glycine after strand S2 and GxND motif). A pseudogene of this gene has been identified on the long arm of chromosome 2. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
Gene Name: | PC-esterase domain containing 1A |
Synonyms: | PCED1A, BA12M19.1, C20orf81, FAM113A, Protein FAM113A, Sarcoma antigen NY-SAR-23 |
Target Sequences: | NM_022760 NP_073597.2 Q9H1Q7 |
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