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FADD

Fas (TNFRSF6)-associated via death domain

FADD is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

Gene Name: Fas (TNFRSF6)-associated via death domain
Synonyms: FADD, GIG3, MORT1, Protein FADD
Target Sequences: NM_003824 NP_003815.1 Q13158

Publications (1)

1
Signaling pathway via TNF-alpha/NF-kappaB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis. Onizawa M, Nagaishi T, Kanai T, Nagano K, Oshima S, Nemoto Y, Yoshioka A, Totsuka T, Okamoto R, Nakamura T, Sakamoto N, Tsuchiya K, Aoki K, Ohya K, Yagita H, Watanabe M. American journal of physiology. Gastrointestinal and liver physiology. 2009 296:G850-9. (WB) [PubMed:19179628]

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Antibodies (94)
Primary (94)
FADD (94)
Human (81)
Mouse (43)
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Monkey (6)
IHC (30)
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WB (89)
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ELISA (31)
ICC (3)
IF (4)
IP (13)
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rabbit (75)
mouse (19)
Product Group
IHCPlus (2)
IgG (52)
IgG1 (13)
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IgG2b (1)
monoclonal mc (19)
polyclonal pc (75)
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APC (2)
APC Conjugated (7)
Azide-free (2)
Biotin Conjugated (9)
Carrier-free (1)
Cy3 Conjugated (2)
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Unconjugated (47)
C-Terminus (10)
pSer191 (9)
aa12-206 (8)
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aa106-135 (7)
pSer194 (5)
130-210 aa (3)
aa1-208 (2)
Ab-191 (1)
Asn188 (1)
Internal (1)
aa101-150 (1)
aa159-208 (1)
aa174-189 (1)
No (94)
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FADD Mouse anti-Human Monoclonal Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$538
FADD Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
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FADD Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
60 µl/$460
FADD Antibody - Western blot of anti-mFADD antibody in mouse heart tissue lysate.mFADD(arrow) was detected using the purified antibody.
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FADD Rabbit anti-Mouse Polyclonal (pSer191) Antibody
Mouse
WB
Unconjugated
400 µl/$393
FADD Antibody - Anti-FADD antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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FADD Rabbit anti-Human Polyclonal (aa159-208) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
FADD Antibody - Immunohistochemical analysis of FADD staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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FADD Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
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FADD Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$331
FADD Antibody - Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using FADD (Phospho-Ser191) Antibody. The picture on the right is blocked with the phospho peptide.
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FADD Rabbit anti-Mouse Polyclonal (pSer191) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
FADD Antibody - Western blot of recombinant FADD.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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FADD Rabbit anti-Mouse Polyclonal (aa7-178) Antibody
Mouse, Human
ICC, IP, WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
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FADD Rabbit anti-Mouse Polyclonal (pSer191) Antibody
Mouse
ELISA, IHC, WB
Unconjugated
200 µl/$734
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FADD Rabbit anti-Mouse Polyclonal (pSer191) (Biotin) Antibody
Mouse
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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FADD Rabbit anti-Mouse Polyclonal (pSer191) (FITC) Antibody
Mouse
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
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FADD Rabbit anti-Mouse Polyclonal (pSer191) (APC) Antibody
Mouse
ELISA, IHC, WB
APC Conjugated
200 µl/$952
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FADD Rabbit anti-Mouse Polyclonal (pSer191) (Azide-free) (HRP) Antibody
Mouse
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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FADD Rabbit anti-Mouse Polyclonal (pSer191) (PE) Antibody
Mouse
ELISA, IHC, WB
PE Conjugated
200 µl/$952
FADD Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue using FADD antibody.
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FADD Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC
Unconjugated
100 µg/$357
FADD Antibody - Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using FADD (Phospho-Ser194) Antibody. The picture on the right is blocked with the phospho peptide.
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FADD Rabbit anti-Human Polyclonal (pSer194) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
FADD Antibody - Western blot of Phospho-FADD (S191) antibody
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FADD Rabbit anti-Mouse Polyclonal (130-210 aa) Antibody
Mouse
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
FADD Antibody - Western blot of FADD antibody
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FADD Rabbit anti-Mouse Polyclonal (130-210 aa) Antibody
Mouse
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
FADD Antibody - Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue, using FADD Antibody. The picture on the right is blocked with the synthesized peptide.
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FADD Rabbit anti-Human Polyclonal (aa101-150) Antibody
Human
IF, IHC, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
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FADD Rabbit anti-Human Polyclonal (pSer194) Antibody
Human
ELISA, ICC, WB
Unconjugated
100 µl/$689
FADD Antibody - Western blot of Phospho-FADD (S194) antibody
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FADD Rabbit anti-Human Polyclonal (pSer194) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
FADD Antibody - Western blot of FADD antibody
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FADD Rabbit anti-Human Polyclonal (130-210 aa) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
FADD Antibody - P-peptide - + Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using FADD (Phospho-Ser191) antibody.
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FADD Rabbit anti-Human Polyclonal (pSer191) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
FADD Antibody - P-peptide - + Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using FADD (Phospho-Ser194) Antibody.
Select
FADD Rabbit anti-Human Polyclonal (pSer194) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
FADD Antibody - Immunohistochemistry of paraffin-embedded human melanoma using antibody at 1:100 dilution.
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FADD Rabbit anti-Human Polyclonal (aa1-208) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).