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FADD
Fas (TNFRSF6)-associated via death domain
FADD is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
| Gene Name: | Fas (TNFRSF6)-associated via death domain |
| Synonyms: | FADD, GIG3, MORT1, Protein FADD |
| Target Sequences: | NM_003824 NP_003815.1 Q13158 |
Publications (1)
1
Signaling pathway via TNF-alpha/NF-kappaB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis. Onizawa M, Nagaishi T, Kanai T, Nagano K, Oshima S, Nemoto Y, Yoshioka A, Totsuka T, Okamoto R, Nakamura T, Sakamoto N, Tsuchiya K, Aoki K, Ohya K, Yagita H, Watanabe M. American journal of physiology. Gastrointestinal and liver physiology. 2009 296:G850-9. (WB)
[PubMed:19179628]
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Publications
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(94)
FADD Mouse anti-Human Monoclonal Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$538
FADD Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
60 µl/$460
FADD Rabbit anti-Mouse Polyclonal (pSer191) Antibody
Mouse
WB
Unconjugated
400 µl/$393
FADD Rabbit anti-Human Polyclonal (aa159-208) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
FADD Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
FADD Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$331
FADD Rabbit anti-Mouse Polyclonal (pSer191) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
FADD Rabbit anti-Mouse Polyclonal (aa7-178) Antibody
Mouse, Human
ICC, IP, WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
FADD Rabbit anti-Mouse Polyclonal (pSer191) Antibody
Mouse
ELISA, IHC, WB
Unconjugated
200 µl/$734
FADD Rabbit anti-Mouse Polyclonal (pSer191) (Biotin) Antibody
Mouse
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
FADD Rabbit anti-Mouse Polyclonal (pSer191) (FITC) Antibody
Mouse
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
FADD Rabbit anti-Mouse Polyclonal (pSer191) (Azide-free) (HRP) Antibody
Mouse
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
FADD Rabbit anti-Mouse Polyclonal (pSer191) (APC) Antibody
Mouse
ELISA, IHC, WB
APC Conjugated
200 µl/$952
FADD Rabbit anti-Mouse Polyclonal (pSer191) (PE) Antibody
Mouse
ELISA, IHC, WB
PE Conjugated
200 µl/$952
FADD Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC
Unconjugated
100 µg/$357
FADD Rabbit anti-Mouse Polyclonal (130-210 aa) Antibody
Mouse
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
FADD Rabbit anti-Human Polyclonal (pSer194) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
FADD Rabbit anti-Mouse Polyclonal (130-210 aa) Antibody
Mouse
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
FADD Rabbit anti-Human Polyclonal (aa101-150) Antibody
Human
IF, IHC, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
FADD Rabbit anti-Human Polyclonal (pSer194) Antibody
Human
ELISA, ICC, WB
Unconjugated
100 µl/$689
FADD Rabbit anti-Human Polyclonal (pSer194) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
FADD Rabbit anti-Human Polyclonal (130-210 aa) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
FADD Rabbit anti-Human Polyclonal (pSer194) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
FADD Rabbit anti-Human Polyclonal (pSer191) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
FADD Rabbit anti-Human Polyclonal (aa1-208) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
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