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F7 / Factor VII is coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Gene Name: | coagulation factor VII (serum prothrombin conversion accelerator) |
Family/Subfamily: | Protease , Serine S1 |
Synonyms: | F7, Coagulation factor VII, Eptacog alfa, F7 Deficiency, Factor 7, Factor VIIa, FVII coagulation protein, Factor VII, FVII, SPCA, Factor VII Deficiency, Proconvertin |
Target Sequences: | NM_000131 NP_000122.1 P08709 |
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