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F3 / CD142 / Tissue factor

coagulation factor III (thromboplastin, tissue factor)

F3 / CD142 / Tissue factor is coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.

Gene Name: coagulation factor III (thromboplastin, tissue factor)
Synonyms: F3, CD142, CD142 antigen, TFA, Tissue factor, Thromboplastin, Coagulation factor III
Target Sequences: NM_001993 NP_001984.1 P13726

Publications (4)

1
Chloroquine reduces hypercoagulability in pancreatic cancer through inhibition of neutrophil extracellular traps. Boone BA, Murthy P, Miller-Ocuin J, Doerfler WR, Ellis JT, Liang X, Ross MA, Wallace CT, Sperry JL, Lotze MT, Neal MD, Zeh HJ 3rd. BMC cancer. 2018 June;18:678. [Full Text Article] [PubMed:29929491] [PMC:PMC6013899]
2
Procoagulant extracellular vesicles in amniotic fluid. Lena Hell, Lukas Wisgrill, Cihan Ay, Andreas Spittler, Michael Schwameis, Bernd Jilma, Ingrid Pabinger, Peter Altevogt, Johannes Thaler. Translational research : the journal of laboratory and clinical medicine. 2017 June;184:12-20.e1. [Full Text Article] [PubMed:28236427] [PMC:PMC6544525]
3
Using annexin V-coated magnetic beads to capture active tissue factor-bearing microparticles from body fluids. Frank Gieseler, Hans Gamperl, Frederike Theophil, Inga Stenzel, Tabea Quecke, Hendrik Ungefroren, Hendrik Lehnert. Cell biology international. 2014 Feburary;38:277-81. [Full Text Article] [PubMed:24431236]
4
Mammalian adipogenesis regulator (Areg) cells use retinoic acid signalling to be non- and anti-adipogenic in age-dependent manner. Magda Zachara , Pernille Y Rainer , Horia Hashimi , Julie M Russeil, Daniel Alpern, Radiana Ferrero, Maria Litovchenko, Bart Deplancke. The EMBO journal. 2022 September;41:e108206. [Full Text Article] [PubMed:35996853] [PMC:PMC9475530]
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Antibodies (140)
Primary (140)
F3 / CD142 / Tissue factor (140)
Human (77)
Mouse (29)
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rabbit (73)
mouse (56)
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aa237-286 (1)
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No (140)
F3 / CD142 / Tissue factor Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
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F3 / CD142 / Tissue factor Mouse anti-Human Monoclonal (HTF-1) Antibody
Human
Flo, ICC, IHC-P, WB
Unconjugated
0.05 mg/$460
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F3 / CD142 / Tissue factor Mouse anti-Human Monoclonal (PE) (HTF-1) Antibody
Human
Flo, Func, ICC, WB
PE Conjugated
100 Tests/$365
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F3 / CD142 / Tissue factor Mouse anti-Human Monoclonal (Extracellular Domain) (TF9-10H10) Antibody
Human
Flo, IF, IHC, IHC-Fr, WB
Unconjugated
0.1 mg/$385
F3 / CD142 / Tissue factor Antibody - Western blot of recombinant F3 / CD142 / Tissue factor.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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F3 / CD142 / Tissue factor Mouse anti-Rabbit Monoclonal (aa33-292) Antibody
Rabbit
WB
Unconjugated
100 µl/$312; 200 µl/$355; 500 µl/$500; 1 ml/$573; 2 ml/$780; 5 ml/$1,268
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F3 / CD142 / Tissue factor Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$332
F3 / CD142 / Tissue factor Antibody - Western blot of recombinant TF / Transferrin.
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F3 / CD142 / Tissue factor Mouse anti-Rat Monoclonal Antibody
Rat
ICC, IP, WB
Unconjugated
100 µl/$312; 200 µl/$355; 500 µl/$500; 1 ml/$573; 2 ml/$780; 5 ml/$1,268
F3 / CD142 / Tissue factor Antibody - Western blot of recombinant TF / Transferrin.
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F3 / CD142 / Tissue factor Mouse anti-Rat Monoclonal (FITC) Antibody
Rat
ICC, IP, WB
FITC Conjugated
100 µl/$352; 200 µl/$413; 500 µl/$625; 1 ml/$780; 2 ml/$1,018; 5 ml/$1,775
F3 / CD142 / Tissue factor Antibody - Immunohistochemistry of paraffin-embedded rat liver using F3 Antibodyat dilution of 1:100 (40x lens).
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F3 / CD142 / Tissue factor Rabbit anti-Human Polyclonal Antibody
Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
F3 / CD142 / Tissue factor Antibody - Western Blot; Sample: Recombinant TF, Human.
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F3 / CD142 / Tissue factor Rabbit anti-Human Polyclonal (aa34-251) Antibody
Human
WB
Unconjugated
100 µl/$299; 200 µl/$337; 500 µl/$463; 1 ml/$527; 2 ml/$682; 5 ml/$1,141
F3 / CD142 / Tissue factor Antibody - Western Blot; Sample: Recombinant TF, Human.
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F3 / CD142 / Tissue factor Rabbit anti-Human Polyclonal (aa34-251) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$325; 200 µl/$375; 500 µl/$539; 1 ml/$632; 2 ml/$867; 5 ml/$1,439
F3 / CD142 / Tissue factor Antibody - Western blot of recombinant F3 / CD142 / Tissue factor.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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F3 / CD142 / Tissue factor Guinea pig anti-Rabbit Polyclonal (aa33-292) Antibody
Rabbit
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
F3 / CD142 / Tissue factor Antibody - Western blot of recombinant F3 / CD142 / Tissue factor.
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F3 / CD142 / Tissue factor Mouse anti-Mouse Monoclonal (aa30-251) Antibody
Mouse
ICC, IP, WB
Unconjugated
100 µl/$307; 200 µl/$348; 500 µl/$486; 1 ml/$555; 2 ml/$742; 5 ml/$1,205
F3 / CD142 / Tissue factor Antibody - Western blot of recombinant F3 / CD142 / Tissue factor.
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F3 / CD142 / Tissue factor Mouse anti-Mouse Monoclonal (aa30-251) (Biotin) Antibody
Mouse
ICC, IP, WB
Biotin Conjugated
100 µl/$317; 200 µl/$362; 500 µl/$513; 1 ml/$589; 2 ml/$812; 5 ml/$1,325
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F3 / CD142 / Tissue factor Mouse anti-Human Monoclonal (Preservative Free) Antibody
Human
ELISA, WB
Unconjugated, Preservative Free
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
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F3 / CD142 / Tissue factor Sheep anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
1 mg/$414
F3 / CD142 / Tissue factor Antibody
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F3 / CD142 / Tissue factor Rabbit anti-Mouse Polyclonal (aa30-251) Antibody
Mouse
WB
Unconjugated
100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
F3 / CD142 / Tissue factor Antibody
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F3 / CD142 / Tissue factor Rabbit anti-Mouse Polyclonal (aa30-251) (PE) Antibody
Mouse
WB
PE Conjugated
100 µl/$392; 200 µl/$470; 500 µl/$798; 1 ml/$951; 2 ml/$1,211; 5 ml/$2,269
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F3 / CD142 / Tissue factor Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, ICC, IF
Unconjugated
100 µl/$412
F3 / CD142 / Tissue factor Antibody - F3 monoclonal antibody (M01), clone 4G4 Western Blot analysis of F3 expression in A-431.
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F3 / CD142 / Tissue factor Mouse anti-Human Monoclonal (4G4) Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$423
F3 / CD142 / Tissue factor Antibody - Immunohistochemistry analysis of paraffin-embedded human brain, using Coagulation Factor III (Phospho-Ser290) Antibody. The picture on the right is blocked with the phospho peptide.
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F3 / CD142 / Tissue factor Rabbit anti-Human Polyclonal (pSer290) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
F3 / CD142 / Tissue factor Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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F3 / CD142 / Tissue factor Rabbit anti-Human Polyclonal (aa33-251) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$460
Select
F3 / CD142 / Tissue factor Rabbit anti-Human Polyclonal (220-300 aa) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
F3 / CD142 / Tissue factor Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
F3 / CD142 / Tissue factor Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC-P, WB
Unconjugated
50 µl/$334; 100 µl/$397
Select
F3 / CD142 / Tissue factor Mouse anti-Human Monoclonal (aa34-251) Antibody
Human
ICC, IP, WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
F3 / CD142 / Tissue factor Antibody - Immunohistochemistry of paraffin-embedded Human gastric cancer using F3 Polyclonal Antibody at dilution of 1:25.
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F3 / CD142 / Tissue factor Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).