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F2 / Prothrombin / Thrombin
coagulation factor II (thrombin)
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Finally, peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
| Gene Name: | coagulation factor II (thrombin) |
| Family/Subfamily: | Protease , Serine S1 |
| Synonyms: | F2, Prothrombin B-chain, Coagulation factor II, FACTOR II, Prothrombin, PT, RPRGL2, Serine protease, THPH1, Thrombin |
| Target Sequences: | NM_000506 NP_000497.1 P00734 |
Publications (3)
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