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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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F13A1 / Factor XIIIa

coagulation factor XIII, A1 polypeptide

F13A1 / Factor XIIIa is the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.

Gene Name: coagulation factor XIII, A1 polypeptide
Synonyms: F13A1, Coagulation factor XIIIa, Factor XIIIa, Fibrinoligase, FSF, A subunit, Transglutaminase. plasma, Transglutaminase A chain, F13A, TGASE
Target Sequences: NM_000129 NP_000120.2 P00488

Filtered by: None
Type
Over-Expression Lysate (2)
Recombinant (8)
Target
F13A1 / Factor XIIIa (10)
Tag
6His,N-terminus (1)
GST (1)
His + T7 (3)
His, C-Terminal (1)
Myc + DDK (3)
Species
Human (6)
Mouse (1)
Rat (1)
West Nile Virus (1)
Source
293T Cells (1)
E. coli (4)
HEK 293 Cells (2)
Human (1)
Wheat Germ Extract (1)
Yeast (1)
Purification
Purified (6)
Low Endotoxin Level
Low endotoxin level (1)
Publications
No (10)
Showing 1-10 of 10 results

Human F13A1 / Factor XIIIa Protein (Recombinant GST) (Full Length) - LS-G28422
Wheat Germ Extract
GST
106.26 kDa
10µg  $425.00; 25µg  $590.00
12.5% SDS-PAGE of human F13A1 stained with Coomassie Blue

Human F13A1 / Factor XIIIa Protein (Recombinant His, C-Terminal) (Gly39-Met732) - LS-G55664
Human
His, C-Terminal
Less than 1.0 EU/µg protein (determined by LAL method).
80.3kD
10µg  $235.00; 50µg  $385.00; 500µg  $1,320.00; 1mg  $1,890.00

Human F13A1 / Factor XIIIa Protein (Recombinant Myc + DDK) (Full Length) - LS-G65275
HEK 293 Cells
Myc + DDK
79.2 kDa
20µg  $890.00
Purified recombinant protein F13A1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining

West Nile Virus F13A1 / Factor XIIIa Protein (Recombinant) - LS-G132270
E. coli
None
12 kDa
50µg  $395.00

Rat F13A1 / Factor XIIIa Protein (Recombinant His + T7) (aa140-377) - LS-G24207
E. coli
His + T7
31.0 kDa
10µg  $295.00; 50µg  $485.00; 100µg  $665.00; 200µg  $980.00; 1mg  $2,520.00
Recombinant  Coagulation Factor XIII A1 Polypeptide By SDS-PAGE

Human F13A1 / Factor XIIIa Protein (Recombinant His + T7) (aa107-345) - LS-G13357
E. coli
His + T7
31.0 kDa
50µg  $445.00; 10µg  $275.00; 200µg  $860.00; 100µg  $590.00; 1mg  $2,205.00
Recombinant Coagulation Factor XIII A1 Polypeptide By SDS-PAGE

Mouse F13A1 / Factor XIIIa Protein (Recombinant His + T7) (aa372-616) - LS-G13358
E. coli
His + T7
31.3 kDa
50µg  $465.00; 10µg  $285.00; 200µg  $905.00; 100µg  $620.00; 1mg  $2,310.00
Recombinant Coagulation Factor XIII A1 Polypeptide By SDS-PAGE

Human F13A1 / Factor XIIIa Protein (Recombinant 6His,N-terminus) (aa39-732) - LS-G57166
Yeast
6His,N-terminus
1mg  $2,205.00; 500µg  $1,395.00; 200µg  $830.00; 100µg  $495.00; 50µg  $355.00; 10µg  $295.00
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Human F13A1 / Factor XIIIa Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G75233
293T Cells
Myc + DDK
83.28 kDa
20µg  $195.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

F13A1 / Factor XIIIa Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G98929
HEK 293 Cells
Myc + DDK
83.28 kDa
100µg  $365.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Showing 1-10 of 10 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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