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F11R / JAM1

F11 receptor

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established.

Gene Name:	F11 receptor
Family/Subfamily:	Immunoglobulin , not assigned-Immunoglobulin
Synonyms:	F11R, CD321, F11 receptor, JAM1, Junctional adhesion molecule 1, Junctional adhesion molecule A, KAT, JAM, JAM-A, JAMA, PAM-1, Platelet F11 receptor, JAM-1, CD321 antigen, JCAM, Platelet adhesion molecule 1
Target Sequences:	NM_016946 NP_058642.1 Q9Y624

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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