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EYA4

eyes absent homolog 4 (Drosophila)

EYA4 is a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator through its protein phosphatase activity, and it may be important for eye development, and for continued function of the mature organ of Corti. Mutations in this gene are associated with postlingual, progressive, autosomal dominant hearing loss at the deafness, autosomal dominant non-syndromic sensorineural 10 locus. The encoded protein is also a putative oncogene that mediates DNA repair, apoptosis, and innate immunity following DNA damage, cellular damage, and viral attack. Defects in this gene are also associated with dilated cardiomyopathy 1J. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene Name: eyes absent homolog 4 (Drosophila)
Synonyms: EYA4, DFNA10, Eyes absent homolog 4, CMD1J, DJ78N10.1 (eyes absent)
Target Sequences: NM_004100 NP_004091.3 O95677

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Proteins (3)
Over-Expression Lysate (2)
Recombinant (1)
EYA4 (3)
No (3)
GST (1)
Myc-DDK (Flag) (2)
Human (2)
293T Cells (1)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Purified (1)
EYA4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
66.9 kDa
20 µg/$150
EYA4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
66.9 kDa
100 µg/$494
EYA4 Protein - 12.5% SDS-PAGE of human EYA4 stained with Coomassie Blue
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Wheat Germ Extract
GST
93.5 kDa
10 µg/$479; 25 µg/$670
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).